VRK1/CK1-IN-1
CAT:
804-HY-158975-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
VRK1/CK1-IN-1
- CAS Number: 3050772-20-5
- UNSPSC Description: VRK1/CK1-IN-1 (compound 36) is a dual inhibitor of vaccinia-related kinase 1 (VRK1) and casein kinase 1 (CK1), with the Ki of 37.9 nM for VRK1 and IC50s of 17 nM and 15 nM for δ and ε isoforms of CK1, respectively[1].
- Target Antigen: Casein Kinase
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/vrk1-ck1-in-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C1N(CC2=CC(C)=NO2)C3=CN=C(NC4=CC(F)=C(O)C(F)=C4)N=C3N(C)[C@H]1C
- Molecular Weight: 416.38
- References & Citations: [1]Fernando H de Souza Gama, et al. Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε. J Med Chem. 2024 May 23.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported