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HBA2 Antibody / Hemoglobin subunit alpha 2

CAT: 0800-F55067-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
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CAT#:0800-F55067-0.2MLSize:0.2 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HBA2 is a key component of hemoglobin, the protein responsible for transporting oxygen from the lungs to the rest of the body. Together with HBA1, this protein forms a tetramer that binds to oxygen molecules and carries them through the bloodstream. While HBA1 is typically more abundant in adults, HBA2 is essential during fetal development and plays a vital role in ensuring the proper oxygenation of tissues in the growing fetus. Research has shown that mutations in the HBA2 gene can lead to various blood disorders, such as alpha-thalassemia, a condition characterized by reduced production of alpha-globin chains.
Specifications
Western blot: 1:1000-1:2000, Flow cytometry: 1:25 per million cells in 0.1ml
UniProt
P69905
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 100-128 from the human protein was used as the immunogen for the HBA2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS
Purity
Antigen affinity purified
Format
Purified
Limitations
This HBA2 antibody is available for research use only.
Storage Conditions
Aliquot the HBA2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HBA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasm
Image Legend
Western blot testing of human fetal heart tissue lysate with HBA2 antibody. Predicted molecular weight ~15 kDa.

UniProtKB · P69905

Hemoglobin subunit alpha

HBA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P69905
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HBA1, HBA2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
P01922, Q1HDT5, Q3MIF5, Q53F97, Q96KF1, Q9NYR7, Q9UCM0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycationGlycoproteinPhosphoprotein

Disease

Disease variantHereditary hemolytic anemia

Ligand

HemeIronMetal-binding

Biological process

Oxygen transportTransport

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