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HLA-B Antibody

CAT: 0800-F55089-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F55089-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
One of the key roles of the HLA-B protein (HLA class I histocompatibility antigen, B alpha chain) is to present fragments of proteins from foreign invaders to our immune cells, specifically T cells. This process, known as antigen presentation, allows our immune system to recognize and target these invaders for destruction. Without a properly functioning HLA-B protein, our immune system would struggle to effectively identify and combat threats. In addition to its role in immune response, HLA-B has also been linked to a variety of health conditions. Certain variations of the HLA-B gene have been associated with an increased risk of autoimmune diseases, such as rheumatoid arthritis and psoriasis. Understanding these genetic factors can help researchers develop personalized treatments that target the underlying causes of these conditions.
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:25 per million cells in 0.1ML
UniProt
P03989
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 62-90 from the human protein were used as the immunogen for the HLA-B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Limitations
This HLA-B antibody is available for research use only.
Storage Conditions
Aliquot the HLA-B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HLA-B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC testing of FFPE human tonsil tissue with HLA-B antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

UniProtKB · P01889

HLA class I histocompatibility antigen, B alpha chain

HLAB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01889
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0A2I6Q7B5, B0V0B8, G3GN01, O02862, O02956, O02957, O02960, O19555, O19556, O19595, O19615, O19624, O19625, O19627, O19641, O19651, O19675, O19692, O19758, O19779, O19783, O46702, O62897, O62901, O62915, O62917, O62919, O77933, O77959, O78053, O78138, O78160, O78163, O78172, O78173, O78180, O78217, O95730, O98140, P01890, P03989, P10317, P10318, P10319, P10320, P18463, P18464, P18465, P19373, P30460, P30461, P30462, P30463, P30464, P30465, P30466, P30467, P30468, P30469, P30470, P30471, P30472, P30473, P30474, P30475, P30476, P30477, P30478, P30479, P30480, P30481, P30482, P30483, P30484, P30485, P30486, P30487, P30488, P30489, P30490, P30491, P30492, P30493, P30494, P30495, P30496, P30497, P30498, P30513, P30685, P79489, P79490, P79496, P79504, P79523, P79524, P79542, P79555, Q04826, Q08136, Q29633, Q29636, Q29638, Q29661, Q29665, Q29678, Q29679, Q29681, Q29693, Q29695, Q29697, Q29718, Q29742, Q29749, Q29762, Q29764, Q29829, Q29836, Q29842, Q29845, Q29846, Q29847, Q29848, Q29850, Q29851, Q29852, Q29854, Q29855, Q29857, Q29858, Q29861, Q29924, Q29925, Q29933, Q29935, Q29936, Q29940, Q29953, Q29961, Q29982, Q30173, Q30198, Q31603, Q31610, Q31612, Q31613, Q546L8, Q546M4, Q5JP37, Q5QT24, Q5RIP1, Q5SRJ2, Q5TK76, Q5TK77, Q860I4, Q861B5, Q8HWF0, Q8MGQ3, Q8MHN4, Q8SNC5, Q95343, Q95344, Q95365, Q95369, Q95392, Q95HA3, Q95HA8, Q95HM9, Q95IA6, Q95IB8, Q95IH5, Q95J00, Q96IT9, Q9BCM6, Q9BCM7, Q9BCM8, Q9BD06, Q9BD38, Q9BD43, Q9GIL3, Q9GIM3, Q9GIX1, Q9GIY5, Q9GIZ0, Q9GIZ9, Q9GJ00, Q9GJ17, Q9GJ20, Q9GJ23, Q9GJ31, Q9GJF0, Q9GJM7, Q9MX21, Q9MY37, Q9MY42, Q9MY43, Q9MY61, Q9MY75, Q9MY78, Q9MY79, Q9MY84, Q9MY92, Q9MY93, Q9MY94, Q9MYB8, Q9MYC3, Q9MYC7, Q9MYF4, Q9MYG1, Q9TP35, Q9TP36, Q9TP37, Q9TP95, Q9TPQ7, Q9TPQ9, Q9TPR2, Q9TPR4, Q9TPS6, Q9TPT2, Q9TPT4, Q9TPT6, Q9TPV2, Q9TQG1, Q9TQH3, Q9TQH6, Q9TQH7, Q9TQH8, Q9TQH9, Q9TQM2, Q9TQN4, Q9TQN6, Q9UQS8, Q9UQT0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityHost-virus interactionImmunityInnate immunity

Cellular component

Cell membraneEndoplasmic reticulumMembraneMHC I

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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