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PECAM Antibody

CAT: 0800-V2781IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2781IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 mAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P16284
Host
Mouse
Reactivity
Human
Immunogen
Prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain downstream of the signal sequence of CD31/PECAM was used as the immunogen for the PECAM antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1A10
Applications
IHC-P
Purity
Unpurified high titer supernatant
Format
Bioreactor concentrate
Limitations
This PECAM antibody is available for research use only.
Storage Conditions
Store the PECAM antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface and cytoplasm of endothelial cells
Image Legend
IHC: Formalin-fixed, paraffin-embedded human tonsil stained with PECAM antibody (1A10)

UniProtKB · P16284

Platelet endothelial cell adhesion molecule

PECA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16284
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PECAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PECAM-1
EC number
—
Processing
Precursor
Secondary accessions
A0A075B738, A8K3S7, D3DU31, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionPhagocytosis

Cellular component

Cell junctionCell membraneMembrane

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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