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Mesothelin Antibody / MSLN

CAT: 0800-V5641-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5641-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
Specifications
Western blot: 1-2 µg/mL
UniProt
Q13421
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 273-407 from human Mesothelin protein was used as the immunogen for the Mesothelin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MSLN/2132
Applications
WB
Purity
Protein G affinity
Format
Purified
Limitations
This Mesothelin antibody is available for research use only.
Storage Conditions
Aliquot the Mesothelin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Mesothelin antibody should be determined by the researcher.
Location
Cell membrane, Golgi apparatus, Secreted
Image Legend
Western blot testing of human OVCAR-3 cell lysate with Mesothelin antibody (clone MSLN/2132) . Predicted molecular weight ~69 kDa (precursor), ~40 kDa (cleaved form) . Glycosylation may make the protein run higher than expected.

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