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Mesothelin Antibody / MSLN

CAT: 0800-V5641SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5641SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
Specifications
Western blot: 1-2 µg/mL
UniProt
Q13421
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 273-407 from human Mesothelin protein was used as the immunogen for the Mesothelin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MSLN/2132
Applications
WB
Purity
Protein G affinity
Format
Purified
Limitations
This Mesothelin antibody is available for research use only.
Storage Conditions
Aliquot the Mesothelin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Mesothelin antibody should be determined by the researcher.
Location
Cell membrane, Golgi apparatus, Secreted
Image Legend
Western blot testing of human OVCAR-3 cell lysate with Mesothelin antibody (clone MSLN/2132) . Predicted molecular weight ~69 kDa (precursor), ~40 kDa (cleaved form) . Glycosylation may make the protein run higher than expected.

UniProtKB · Q13421

Mesothelin

MSLN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13421
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MSLN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3DU65, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneGolgi apparatusMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinGPI-anchorLipoproteinPhosphoprotein

Domain

Signal

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