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Periostin Antibody / POSTN

CAT: 0800-V5651-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5651-100UGSize:100 µg
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Description
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVbeta3 and AlphaVbeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1) . Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q15063
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 193-326 from human POSTN protein was used as the immunogen for the Periostin antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
POSTN/4095
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This Periostin antibody is available for research use only.
Storage Conditions
Aliquot the Periostin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Periostin antibody should be determined by the researcher.
Location
Secreted, Cytoplasm
Image Legend
IHC staining of FFPE human adrenal gland tissue with Periostin antibody (clone POSTN/4095) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q15063

Periostin

POSTN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15063
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
POSTN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PN
EC number
—
Processing
Precursor
Secondary accessions
B1ALD8, B1ALD9, C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628, Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

PTM

Disulfide bondGamma-carboxyglutamic acidGlycoprotein

Cellular component

Extracellular matrixGolgi apparatusSecreted

Molecular function

Heparin-binding

Domain

RepeatSignal

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