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MBP Antibody / Myelin basic protein

CAT: 0800-V5763-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V5763-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin. MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P02686
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-100 from human Myelin basic protein was used as the immunogen for the MBP antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2b κ
Clone
RMBP/9431
Applications
IHC-P, WB
Purity
Protein G affinity
Format
Purified
Limitations
This MBP antibody is available for research use only.
Storage Conditions
Aliquot the MBP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MBP antibody should be determined by the researcher.
Location
Cell membrane, Myelin membrane
Image Legend
IHC staining of FFPE human brain tissue with MBP antibody (clone rMBP/9431) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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