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Cyclin D1 Antibody

CAT: 0800-V5786-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5786-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 100-295 from human Cyclin D1 protein was used as the immunogen for the Cyclin D1 antibody.
Clonality
Monoclonal
Isotype
IgG κ
Clone
CCND1/12039
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Limitations
This Cyclin D1 antibody is available for research use only.
Storage Conditions
Aliquot the Cyclin D1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Cyclin D1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
IHC staining of FFPE human thyroid tissue with Cyclin D1 antibody (clone CCND1/12039) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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