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2-Benzoxazolinone

CAT: 0804-HY-W015818-01Size: 50 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W015818-01Size:50 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2 (3H) -one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4].
CAS Number
59-49-4
Product Name Alternative
2-Benzoxazolone; 1,3-Benzoxazol-2 (3H) -one; 2-Hydroxybenzoxazole
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/2-Benzoxazolinone.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 3.85 mg/mL (ultrasonic)
Smiles
O=C1OC2=CC=CC=C2N1
Molecular Formula
C7H5NO2
Molecular Weight
135.12
Precautions
H302+H312+H332
References & Citations
[1]Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60 (2) :187-8.|[2]Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus) . Plant Physiology and Biochemistry 44 (11-12) :819-27|[3]Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2 (3H) -one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70 (2) :245-53.|[4]Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2 (3H) -one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62 (7) :330-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Leishmania

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