TH Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008], catalytic activity:L-tyrosine + tetrahydrobiopterin + O (2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin., cofactor:Fe (2+) ion., disease:Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA., enzyme regulation:Phosphorylation leads to an increase in the catalytic activity., function:Plays an important role in the physiology of adrenergic neurons., online information:Tyrosine hydroxylase entry, pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2., similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family., tissue specificity:Mainly expressed in the brain and adrenal glands.

• Product Name Alternative:

  TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH

• Gene Name:

  TH

• Gene ID:

  7054

• Swiss Prot:

  P07101

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, ELISA

• Field of Research:

  Tyrosine metabolism; Parkinson's disease

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  55kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG