CD35 Rabbit Polyclonal Antibody

• Background:

  This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variantsfunction:Mediates cellular binding of particles and immune complexes that have activated complement., miscellaneous:This is the sequence of the F allotype of CR1., online information:Blood group antigen gene mutation database, polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl (a) /Vil (Kn4, or Swain-Langley; Vil or Villien) . Sl (a-) phenotype is more common in persons of African descent and may protect against fatal malaria., similarity:Belongs to the receptors of complement activation (RCA) family., similarity:Contains 30 Sushi (CCP/SCR) domains., subunit:Monomer., tissue specificity:Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

• Product Name Alternative:

  Complement component (3b/4b) receptor 1/2 (Knops blood group)

• Gene ID:

  1378

• Swiss Prot:

  P17927/Q2VPA4

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Field of Research:

  Complement and coagulation cascades; Hematopoietic cell lineage

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  220kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG