CdcA7 Rabbit Polyclonal Antibody

• Background:

  Cell division cycle associated 7 (CDCA7) Homo sapiens This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008], function:Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator., induction:Activated by MYC and possibly E2F1., miscellaneous:CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines., tissue specificity:Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.

• Product Name Alternative:

  CDCA7; JPO1; Cell division cycle-associated protein 7; Protein JPO1

• Gene Name:

  CDCA7

• Gene ID:

  83879

• Swiss Prot:

  Q9BWT1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  43kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG