Vitronectin Rabbit Polyclonal Antibody

• Background :

  The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008], domain:The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin., function:Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity., function:Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway., PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both., PTM:N- and O-glycosylated., PTM:Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading., PTM:Sulfated on 2 tyrosine residues., similarity:Contains 1 SMB (somatomedin-B) domain., similarity:Contains 4 hemopexin-like domains., subunit:Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin., tissue specificity:Plasma.

• Product Name Alternative :

  VTN; Vitronectin; VN; S-protein; Serum-spreading factor; V75

• Gene Name :

  VTN

• Gene ID :

  7448

• Swiss Prot :

  P04004

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB, ELISA

• Field of Research :

  Focal adhesion; ECM-receptor interaction

• Purification :

  Affinity purification

• Dilution :

  WB 1:500-1:2000, ELISA 1:5000-1:20000

• Form :

  Liquid

• Buffer :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification :

  Unmodified

• Molecular Weight :

  55kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype :

  IgG