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PCNT Rabbit Polyclonal Antibody

CAT: 1444-APRab15856-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab15856-01Size:20 µL
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Background
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM) . The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015], disease:Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2) [MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence., function:An integral component of the pericentriolar material (PCM) ., subcellular location:Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization., subunit:Interacts with PCM1. Binds calmodulin., tissue specificity:Expressed in all tissues tested, including placenta, liver, kidney and thymus.
Gene Name
PCNT KIAA0402 PCNT2
Gene ID
5116
Swiss Prot
O95613
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF
Purification
Affinity purification
Dilution
IHC 1:50-1:300, ICC/IF 1:50-1:200
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
366kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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