PCNT Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM) . The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015], disease:Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2) [MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition have an average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normal intelligence., function:An integral component of the pericentriolar material (PCM) ., subcellular location:Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization., subunit:Interacts with PCM1. Binds calmodulin., tissue specificity:Expressed in all tissues tested, including placenta, liver, kidney and thymus.

• Gene Name:

  PCNT KIAA0402 PCNT2

• Gene ID:

  5116

• Swiss Prot:

  O95613

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC, ICC/IF

• Purification:

  Affinity purification

• Dilution:

  IHC 1:50-1:300, ICC/IF 1:50-1:200

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  366kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG