LIGHT Rabbit Polyclonal Antibody

CAT: 1444-APRab13305-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab13305-01Size:20 µL
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Background
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM) . This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008], function:Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus., induction:Up-regulated after T-cell activation., PTM:N-glycosylated., PTM:The soluble form of isoform 1 derives from the membrane form by proteolytic processing., similarity:Belongs to the tumor necrosis factor family., subunit:Homotrimer., tissue specificity:Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Product Name Alternative
TNFSF14; HVEML; LIGHT; Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD antigen CD258
Gene Name
TNFSF14
Gene ID
8740
Swiss Prot
O43557
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC
Field of Research
Cytokine-cytokine receptor interaction
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:50-1:300
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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