SIK1 Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ., subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182., catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39., function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 UBA domain., subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ., subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.

SIK1; SIK; SNF1LK; Serine/threonine-protein kinase SIK1; Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK

SIK1

150094

P57059

Human, Rat

Unconjugated

WB, IHC

Affinity purification

WB 1:500-1:2000, IHC 1:50-1:300

Liquid

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Unmodified

85kDa

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.