MCAD Rabbit Polyclonal Antibody

CAT: 1444-APRab13701-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab13701-01Size:20 µL
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Background
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], catalytic activity:Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor., cofactor:FAD., disease:Defects in ACADM are the cause of medium-chain acyl-CoA dehydrogenase deficiency (MCAD deficiency) [MIM:201450]. It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. The disease frequency is one in 13000., function:This enzyme is specific for acyl chain lengths of 4 to 16., miscellaneous:A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues., miscellaneous:Utilizes the electron transfer flavoprotein (ETF) as electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) ., pathway:Lipid metabolism; mitochondrial fatty acid beta-oxidation., similarity:Belongs to the acyl-CoA dehydrogenase family., subunit:Homotetramer. Interacts with the heterodimeric electron transfer flavoprotein ETF.
Product Name Alternative
ACADM; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD
Gene Name
ACADM
Gene ID
34
Swiss Prot
P11310
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC
Field of Research
Fatty acid metabolism; Valine; leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; PPAR
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:50-1:300
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
46kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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