CD166 Rabbit Polyclonal Antibody

• Background:

  This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011], domain:The CD6 binding site is located in the N-terminal Ig-like domain., function:Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system., similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., tissue specificity:Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.

• Product Name Alternative:

  ALCAM; MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD166

• Gene Name:

  ALCAM

• Gene ID:

  214

• Swiss Prot:

  Q13740

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ICC/IF, ELISA

• Field of Research:

  Cell adhesion molecules (CAMs)

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  65kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG