SR-2A Rabbit Polyclonal Antibody

• Background:

  This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD) . MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009], domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4., function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production., online information:The Singapore human mutation and polymorphism database, similarity:Belongs to the G-protein coupled receptor 1 family., subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses., subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.

• Product Name Alternative:

  HTR2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A

• Gene Name:

  HTR2A

• Gene ID:

  3356

• Swiss Prot:

  P28223

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC, ICC/IF, ELISA

• Field of Research:

  Calcium; Neuroactive ligand-receptor interaction; Gap junction

• Purification:

  Affinity purification

• Dilution:

  IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:5000-1:10000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG