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VU0418506

CAT: 0804-HY-120068Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120068Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0418506 is a selective positive allosteric modulator of mGlu4, with EC50 values of 68 nM and 46 nM for hmGlu4 and rmGlu4, respectively. VU0418506 exhibits antiparkinsonian activity[1][2].
CAS Number
1330624-42-4
UNSPSC
12352005
Hazard Statement
H302
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0418506.html
Smiles
FC1=CC=C(NC2=NNC3=C2N=CC=C3)C=C1Cl
Molecular Formula
C12H8ClFN4
Molecular Weight
262.67
Precautions
P264-P270-P330-P501
References & Citations
[1]Darren W Engers, et al. Discovery, Synthesis, and Preclinical Characterization of N- (3-Chloro-4-fluorophenyl) -1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) . ACS Chem Neurosci. 2016 Sep 21;7 (9) :1192-200.|[2]Colleen M Niswender, et al. Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1201-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5778792VU0418506

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