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Pronethalol

CAT: 0804-HY-B1238-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1238-01Size:5 mg
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Description
Pronethalol ((±) -Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs) [1][2].
CAS Number
54-80-8
Product Name Alternative
(±) -Pronethalo
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Pronethalol.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1
Molecular Formula
C15H19NO
Molecular Weight
229.32
References & Citations
[1]Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129 (8) :3121-3133.|[2]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-508.|[3]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

Chemical Information

Pronethalol

Pronethalol is a member of naphthalenes.

CAS Number54-80-8
PubChem CID4930
IUPAC Name1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol
Molecular FormulaC15H19NO
Molecular Weight229.32
XLogP3
Topological Polar Surface Area32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity229
SMILES
CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O
InChI
InChI=1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3
InChIKey
HRSANNODOVBCST-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pronethalol
CAS: 54-80-8
CID: 4930
Formula: C15H19NO
MW: 229.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight229.32
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass229.146664230
Monoisotopic Mass229.146664230
Topological Polar Surface Area32.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity229
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
sc-471829(+/-) -Pronethalol
BA5105-100Pronethalol
TRC-P757170-1G(+/-)-Pronethalol
B5023-10Pronethalol hydrochloride
sc-476058(+/-) -Pronethalol-d6
FP27185(+/-) -Pronethalol HCl

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