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JNK2 Polyclonal Antibody

CAT: 0763-D-AB-10207L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10207L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Abbreviation
JNK2
UniProt
P49186
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human MAPK9 protein expressed by E.coli
Target
C Jun kinase 2; C Jun N terminal kinase 2; c-Jun N-terminal kinase 2; JNK 55; JNK-55; JNK2 alpha; JNK2; JNK2 beta; JNK2A; JNK2alpha; JNK2B; JNK2BETA; Jun kinase; MAP kinase 9; MAPK 9; Mapk9; Mitogen activated protein kinase 9; Mitogen-activated protein kinase 9; MK09_HUMAN; P54a; p54aSAPK; PRKM9; Protein kinase; mitogen-activated; 9; SAPK alpha; SAPK; SAPK1a; Stress activated protein kinase 1a; Stress-activated protein kinase JNK2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cell Biology; Cancer; Immunology; Metabolism
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:5000-1:10000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
48kDa
Observed Molecular Weight
46kDa,54kDa
Isotype
IgG

UniProtKB · P49186

Mitogen-activated protein kinase 9

MK09_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P49186
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mapk9
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
MAP kinase 9, MAPK 9
EC number
2.7.11.24
Processing
—
Secondary accessions
—
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythms

Cellular component

CytoplasmNucleus

Technical term

Direct protein sequencingReference proteome

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein
Product Datasheet
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