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Tolazamide

CAT: 0804-HY-B0920-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0920-01Size:5 mg
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Description
Tolazamide (U-17835) is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (IC50 = 4.2 µM in HEK293 cells transfected with the human receptor) . Tolazamide has anti-diabetic properties. Tolazamide can lower blood glucose in sulfonylurea class. Tolazamide decreases insulin dose while continuing to maintain adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA[1][2][3].
CAS Number
1156-19-0
Product Name Alternative
U-17835
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Tolazamide.html
Purity
99.94
Solubility
DMSO : ≥ 39 mg/mL
Smiles
O=S(C1=CC=C(C)C=C1)(NC(NN2CCCCCC2)=O)=O
Molecular Formula
C14H21N3O3S
Molecular Weight
311.40
Precautions
H302
References & Citations
[1]Mustafa Karakaya, et al., (2015) Theoretical and experimental investigations on vibrational and structural properties of tolazamide, Journal of Molecular Structure, Volume 1095, Pages 87-95, ISSN 0022-2860. |[2]Gopalakrishnan, M., et al., (2000) . Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K (+) channel Kir6.2 combination expressed in HEK-293 cells. British journal of pharmacology, 129 (7), 1323–1332.|[3]Kabadi U. M. (1985) . Adjuvant therapy with tolazamide and insulin improves metabolic control in type I diabetes mellitus. Diabetes care, 8 (5), 440–446.|[4]McCormick, K., et al., (1986) . Effect of tolazamide on basal ketogenesis, glycogenesis, and gluconeogenesis in liver obtained from normal and diabetic rats. Endocrinology, 119 (3), 1268–1273.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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