2-Hexynyl-5′-N-ethylcarboxamidoadenosine

2-Hexynyl-5′-N-ethylcarboxamidoadenosine

• CAS Number: 141018-30-6
• UNSPSC Description: 2-Hexynyl-5′-N-ethylcarboxamidoadenosine (HENECA) is a selective A2A adenosine receptor agonist. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine increases intracellular cAMP level, and inhibits TNFα-evoked MMP-3 release. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine induces Aβ42 production in SH-SY5Y cells[1][2][3].
• Target Antigen: Adenosine Receptor; Amyloid-β
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/2-hexynyl-5-n-ethylcarboxamidoadenosine.html
• Smiles: O[C@H]([C@@H]1O)[C@](O[C@@H]1C(NCC)=O)([H])N2C3=NC(C#CCCCC)=NC(N)=C3N=C2
• Molecular Weight: 388.42
• References & Citations: [1]Cunha RA, et al. ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. Br J Pharmacol. 1997 Dec;122(7):1279-84.|[2]Konishi H, et al. Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A2A receptor signaling. Sci Rep. 2022 Apr 11;12(1):6033|[3]Nagpure BV, et al. Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. PLoS One. 2014 Feb 11;9(2):e88508.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported