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CHPG

CAT: 0804-HY-101364-03Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101364-03Size:50 mg
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Description
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
CAS Number
170846-74-9
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Akt; ERK; mGluR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chpg.html
Purity
99.51
Solubility
1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 25 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)
Smiles
O=C(O)C(N)C1=CC(O)=CC=C1Cl
Molecular Formula
C8H8ClNO3
Molecular Weight
201.61
Precautions
H302, H312, H332
References & Citations
2
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; mGluR5; NF-κB
Citation 01
IBRO Neurosci Rep. 2025 May 26:18:823-829.|World J Gastroenterol. 2025 Feb 21;31 (7) :98852. |Immunobiology. 2025 Jun 28;230 (4) :153095.|SSRN. 2025 Aug 27.

Chemical Information

2-Chloro-5-hydroxyphenylglycine

activates mGlu(5) receptors; structure in first source

CAS Number170846-74-9
PubChem CID3645780
IUPAC Name2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
Molecular FormulaC8H8ClNO3
Molecular Weight201.61
XLogP-1.4
Topological Polar Surface Area83.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count13
Formal Charge0
Complexity200
SMILES
C1=CC(=C(C=C1O)C(C(=O)O)N)Cl
InChI
InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
InChIKey
UNIDAFCQFPGYJJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Chloro-5-hydroxyphenylglycine
CAS: 170846-74-9
CID: 3645780
Formula: C8H8ClNO3
MW: 201.61
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight201.61
XLogP3-1.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass201.0192708
Monoisotopic Mass201.0192708
Topological Polar Surface Area83.6 Ų
Heavy Atom Count13
Formal Charge0
Complexity200
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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