CEP-37440

CAT: 0804-HY-15841-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15841-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397) [1][2].
CAS Number
[1391712-60-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Anaplastic lymphoma kinase (ALK) ; FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CEP-37440.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C4C(CCC[C@H](N5CCN(CCO)CC5)C4)=C3OC)=NC=C2Cl
Molecular Formula
C30H38ClN7O3
Molecular Weight
580.12
Precautions
H302
References & Citations
[1]Salem I, et, al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breast Cancer Res. 2016 Mar 24;18 (1) :37.|[2]Ott GR, et, al. Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK) . J Med Chem. 2016 Aug 25;59 (16) :7478-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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Alternative Products

CatalogName
TRC-C256690-100MGCEP-37440
A15543-25CEP-37440 25mg
A15543-1CEP-37440 1mg
A15543-2CEP-37440 2mg
A15543-10CEP-37440 10mg
A15543-50CEP-37440 50mg
A15543-100CEP-37440 100mg
A15543-5CEP-37440 5mg
MF-0160948-01Compound EN300-37440
8108/5CEP

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