MitoSOX Red

• Description :

  MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm.

• UNSPSC :

  12171500

• Target :

  Fluorescent Dye; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

• Type :

  Dye Reagents

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mitosox-red.html

• Purity :

  96.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC1=CC(C(C2=CC=CC=C2)N(CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(N)=CC=C76)=C7C=C1.[I-]

• Molecular Formula :

  C43H43IN3P

• Molecular Weight :

  759.70

• References & Citations :

  [1]Price OT, et al. Quantitative fluorescence of 5-FU-treated fetal rat limbs using confocal laser scanning microscopy and Lysotracker Red. Cytometry A. 2003;53 (1) :9-21.|[2]Fengjiao Jin, et al. The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility. Cancer Biol Med. 2019 Feb;16 (1) :38-54.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [1003197-00-9]