Products for Research Use Only

MitoSOX Red

CAT: 0804-HY-D1055-01Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1055-01Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm.
CAS Number
1003197-00-9
UNSPSC
12171500
Target
Fluorescent Dye; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Dye Reagents
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mitosox-red.html
Purity
96.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC(C(C2=CC=CC=C2)N(CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC(N)=CC=C76)=C7C=C1.[I-]
Molecular Formula
C43H43IN3P
Molecular Weight
759.70
References & Citations
[1]Price OT, et al. Quantitative fluorescence of 5-FU-treated fetal rat limbs using confocal laser scanning microscopy and Lysotracker Red. Cytometry A. 2003;53 (1) :9-21.|[2]Fengjiao Jin, et al. The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility. Cancer Biol Med. 2019 Feb;16 (1) :38-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported