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Tocainide hydrochloride

CAT: 1410-M37617-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M37617-02Size:1 mL x 10 mM in DMSO
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Description
Tocainide hydrochloride (2-amino-n- (2,6-dimethylphenyl) propanamide hydrochloride) is a sodium channel blocker. It blocks the sodium channels in the pain-producing foci in the nerve membranes.
CAS Number
35891-93-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
228.72
Molecular Formula
C11H17ClN2O
Notes
Research use only, not for human use.
Receptor
Sodium Channel

Chemical Information

Tocainide Hydrochloride

Tocainide Hydrochloride is the hydrochloride salt form of tocainide, a primary amine analog of lidocaine exhibiting class 1b antiarrhythmic property. Tocainide hydrochloride stabilizes the neuronal membrane by reversibly binding to and blocking open and inactivated voltage-gated sodium channels. This inhibits the inward sodium current required for the initiation and conduction of impulses and reduces the excitability of myocardial cells. This agent reduces the rate of rise and amplitude, and shortens the action-potential duration (APD) in both the Purkinje and muscle fibers. Tocainide also shortens the effective refractory period (ERP) of Purkinje fibers resulting in an increased the ERP/APD ratio. Overall these effects lead to the slowing of nerve impulses and stabilization of the heartbeat.

CAS Number35891-93-1
PubChem CID108173
IUPAC Name2-amino-N-(2,6-dimethylphenyl)propanamide;hydrochloride
Molecular FormulaC11H17ClN2O
Molecular Weight228.72
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity195
SMILES
CC1=C(C(=CC=C1)C)NC(=O)C(C)N.Cl
InChI
InChI=1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
InChIKey
AMZACPWEJDQXGW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tocainide Hydrochloride
CAS: 35891-93-1
CID: 108173
Formula: C11H17ClN2O
MW: 228.72
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight228.72
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass228.1029409
Monoisotopic Mass228.1029409
Topological Polar Surface Area55.1 Ų
Heavy Atom Count15
Formal Charge0
Complexity195
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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