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C 101248

CAT: 1410-M37356-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M37356-05Size:100 mg
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Description
C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.
CAS Number
361368-24-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
292.3
Molecular Formula
C15H12N6O
Notes
Research use only, not for human use.
Receptor
Others

Chemical Information

Kcnk13-IN-1
CAS Number361368-24-3
PubChem CID723233
IUPAC Name4-[1-(pyridin-4-ylmethyl)benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
Molecular FormulaC15H12N6O
Molecular Weight292.30
XLogP1.1
Topological Polar Surface Area95.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity377
SMILES
C1=CC=C2C(=C1)N=C(N2CC3=CC=NC=C3)C4=NON=C4N
InChI
InChI=1S/C15H12N6O/c16-14-13(19-22-20-14)15-18-11-3-1-2-4-12(11)21(15)9-10-5-7-17-8-6-10/h1-8H,9H2,(H2,16,20)
InChIKey
LXADAVBNVFYEBW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Kcnk13-IN-1
CAS: 361368-24-3
CID: 723233
Formula: C15H12N6O
MW: 292.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.30
XLogP31.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass292.10725903
Monoisotopic Mass292.10725903
Topological Polar Surface Area95.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity377
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
8007/10C 101248

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