C 101248

• Description:

  C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  292.3

• Molecular Formula:

  C15H12N6O

• Notes:

  Research use only, not for human use.

• Receptor:

  Others

• CAS Number:

  361368-24-3