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C 101248

CAT: 1410-M37356-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M37356-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.
CAS Number
361368-24-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
292.3
Molecular Formula
C15H12N6O
Notes
Research use only, not for human use.
Receptor
Others

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