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12R-LOX-IN-2

CAT: 1410-M37042-01Size: 1 EachDry Ice: NoHazardous: No
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Description
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX) .12R-LOX-IN-2 inhibits imiquimod (IMQ) -induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 may be useful in the study of psoriasis and other skin-associated inflammatory diseases.
CAS Number
3026677-37-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
271.31
Molecular Formula
C19H13NO
Notes
Research use only, not for human use.
Receptor
Lipoxygenase

Chemical Information

12R-Lox-IN-2
CAS Number3026677-37-9
PubChem CID168679704
IUPAC Name4-quinolin-2-ylnaphthalen-1-ol
Molecular FormulaC19H13NO
Molecular Weight271.3
XLogP4.7
Topological Polar Surface Area33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity357
SMILES
C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C4=CC=CC=C43)O
InChI
InChI=1S/C19H13NO/c21-19-12-10-15(14-6-2-3-7-16(14)19)18-11-9-13-5-1-4-8-17(13)20-18/h1-12,21H
InChIKey
PLATVCRZPNTREE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 12R-Lox-IN-2
CAS: 3026677-37-9
CID: 168679704
Formula: C19H13NO
MW: 271.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight271.3
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass271.099714038
Monoisotopic Mass271.099714038
Topological Polar Surface Area33.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity357
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS581938012R-LOX-IN-2
HY-15524312R-LOX-IN-1
123246ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12)
123246-HRPALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (HRP)
123246-FITCALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (FITC)
123246-BiotinALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (Biotin)
123246-APCALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (APC)
MBS6156484-01ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (PE)
MBS6135272-01ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) APC
MBS6129969-01ALOX12B (Arachidonate 12-lipoxygenase, 12R-type, 12R-LOX, 12R-lipoxygenase, Epidermis-type Lipoxygenase 12) (AP)

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