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EN450

CAT: 1410-M36937-03Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M36937-03Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be used to study leukemia.
CAS Number
793719-01-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
288.75
Molecular Formula
C11H13ClN2O3S
Notes
Research use only, not for human use.
Receptor
NF-κB

Chemical Information

N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
CAS Number793719-01-4
PubChem CID4877041
IUPAC NameN-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
Molecular FormulaC11H13ClN2O3S
Molecular Weight288.75
XLogP1.3
Topological Polar Surface Area74.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity416
SMILES
CN(C)S(=O)(=O)C1=CC(=C(C=C1)Cl)NC(=O)C=C
InChI
InChI=1S/C11H13ClN2O3S/c1-4-11(15)13-10-7-8(5-6-9(10)12)18(16,17)14(2)3/h4-7H,1H2,2-3H3,(H,13,15)
InChIKey
OXFXDOLAQBMOPH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[2-chloro-5-(dimethylsulfamoyl)phenyl]prop-2-enamide
CAS: 793719-01-4
CID: 4877041
Formula: C11H13ClN2O3S
MW: 288.75
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight288.75
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass288.0335411
Monoisotopic Mass288.0335411
Topological Polar Surface Area74.9 Ų
Heavy Atom Count18
Formal Charge0
Complexity416
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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