CDK8-IN-12

• Description:

  CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  381.86

• Molecular Formula:

  C21H20ClN3O2

• Notes:

  Research use only, not for human use.

• Receptor:

  GSK-3 | CDK

• CAS Number:

  2613307-67-6