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ASC-JM-17

CAT: 1410-M36370-01Size: 1 EachDry Ice: NoHazardous: No
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Description
ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies.
CAS Number
1039760-91-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
464.55
Molecular Formula
C28H32O6
Notes
Research use only, not for human use.
Receptor
Others

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