Products for Research Use Only
RegisterLogin

AP23846

CAT: 1410-M36255-01Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M36255-01Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.
CAS Number
878654-51-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
439.53
Molecular Formula
C24H34N5OP
Notes
Research use only, not for human use.
Receptor
Src

Chemical Information

AP-23846

Src Kinase Inhibitor AP 23846 is a novel small molecule Src family kinase inhibitor with potential antiangiogenic activity. Upon administration, Src kinase inhibitor AP23846 selectively binds to and stabilizes an inactive ATP-binding site conformation leading to reduced Src kinase activity. This may reduce the production of pro-angiogenic factors, vascular endothelial growth factor (VEGF) and interleukin (IL)-8. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation, survival, migration, invasion and angiogenesis.

CAS Number878654-51-4
PubChem CID11647855
IUPAC Name2-cyclopentyl-N-(4-dipropylphosphorylphenyl)-9-ethylpurin-6-amine
Molecular FormulaC24H34N5OP
Molecular Weight439.5
XLogP4.7
Topological Polar Surface Area72.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count31
Formal Charge0
Complexity595
SMILES
CCCP(=O)(CCC)C1=CC=C(C=C1)NC2=C3C(=NC(=N2)C4CCCC4)N(C=N3)CC
InChI
InChI=1S/C24H34N5OP/c1-4-15-31(30,16-5-2)20-13-11-19(12-14-20)26-23-21-24(29(6-3)17-25-21)28-22(27-23)18-9-7-8-10-18/h11-14,17-18H,4-10,15-16H2,1-3H3,(H,26,27,28)
InChIKey
QWYGJEVWFGFNRP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AP-23846
CAS: 878654-51-4
CID: 11647855
Formula: C24H34N5OP
MW: 439.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.5
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass439.25009772
Monoisotopic Mass439.25009772
Topological Polar Surface Area72.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity595
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP03823-01AP23846

Popular Products