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LY3372689

CAT: 1410-M35580-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M35580-01Size:5 mg
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Description
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
CAS Number
2241514-56-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
383.44
Molecular Formula
C16H22FN5O3S
Notes
Research use only, not for human use.
Receptor
Microtubule Associated

Chemical Information

LY3372689

Ceperognastat is a small molecule drug. Ceperognastat is under investigation in clinical trial NCT05063539 (A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease). Ceperognastat has a monoisotopic molecular weight of 383.14 Da.

CAS Number2241514-56-5
PubChem CID135260636
IUPAC NameN-[4-fluoro-5-[[(2S,4S)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]piperidin-1-yl]methyl]-1,3-thiazol-2-yl]acetamide
Molecular FormulaC16H22FN5O3S
Molecular Weight383.4
XLogP1.8
Topological Polar Surface Area122
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count26
Formal Charge0
Complexity491
SMILES
C[C@H]1C[C@H](CCN1CC2=C(N=C(S2)NC(=O)C)F)OCC3=NOC(=N3)C
InChI
InChI=1S/C16H22FN5O3S/c1-9-6-12(24-8-14-19-11(3)25-21-14)4-5-22(9)7-13-15(17)20-16(26-13)18-10(2)23/h9,12H,4-8H2,1-3H3,(H,18,20,23)/t9-,12-/m0/s1
InChIKey
FRVXHWNHGWUTQO-CABZTGNLSA-N
Chemical Structure
2D Structure
2D structure of LY3372689
CAS: 2241514-56-5
CID: 135260636
Formula: C16H22FN5O3S
MW: 383.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.4
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass383.14273892
Monoisotopic Mass383.14273892
Topological Polar Surface Area122 Ų
Heavy Atom Count26
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8557-10LY3372689
HY-144682(2R,4R) -LY3372689

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