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MMRi62

CAT: 1410-M35377-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M35377-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMRi62 (7-[ (2,3-dichlorophenyl) - (pyridin-2-ylamino) methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53) . MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1) . MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
CAS Number
352693-80-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
396.27
Molecular Formula
C21H15Cl2N3O
Notes
Research use only, not for human use.
Receptor
Ferroptosis

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