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MMRi62

CAT: 0931-T60202-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T60202-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
352693-80-2
Target
Apoptosis, Ferroptosis, Autophagy, MDM-2/p53, Ras, Kras
Related Pathways
Apoptosis, Autophagy, MAPK
Purity
0.9987
Bioactivity
MMRi62 (7-[ (2,3-dichlorophenyl) - (pyridin-2-ylamino) methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53) . MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1) . MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
Smiles
Oc1c(ccc2cccnc12)C(Nc1ccccn1)c1cccc(Cl)c1Cl
Molecular Formula
C21H15Cl2N3O
Molecular Weight
396.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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