A-674563 HCl (552325-73-2 (free base) )

• Description:

  A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) . It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families .

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  394.9

• Molecular Formula:

  C22H23ClN4O

• Notes:

  Research use only, not for human use.

• Receptor:

  CDK | ERK | PKA | PKC | Akt

• CAS Number:

  2070009-66-2