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TASP 0277308

CAT: 1410-M35256-01Size: 1 EachDry Ice: NoHazardous: No
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Description
TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM) . TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia.
CAS Number
945725-50-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
539.48
Molecular Formula
C23H28Cl2N6O3S
Notes
Research use only, not for human use.
Receptor
Others

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