JAK2-IN-6

• Description:

  JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL) . Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  335.83

• Molecular Formula:

  C14H10ClN3OS2

• Notes:

  Research use only, not for human use.

• Receptor:

  JAK

• CAS Number:

  353512-04-6