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JAK2 Inhibitor V

CAT: 1410-M18188-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M18188-01Size:2 mg
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Description
NSC 42834 (JAK2 Inhibitor V, Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.
CAS Number
195371-52-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
344.45
Molecular Formula
C23H24N2O
Notes
Research use only, not for human use.
Receptor
JAK2| JAK2 (V617F)

Chemical Information

2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one

a Jak2 tyrosine kinase inhibitor; structure in first source

CAS Number195371-52-9
PubChem CID238484
IUPAC Name2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
Molecular FormulaC23H24N2O
Molecular Weight344.4
XLogP4.5
Topological Polar Surface Area42.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Heavy Atom Count26
Formal Charge0
Complexity408
SMILES
CC(CCC1=CC=CC=N1)(CCC2=CC=CC=N2)C(=O)C3=CC=CC=C3
InChI
InChI=1S/C23H24N2O/c1-23(15-13-20-11-5-7-17-24-20,16-14-21-12-6-8-18-25-21)22(26)19-9-3-2-4-10-19/h2-12,17-18H,13-16H2,1H3
InChIKey
SETYDCSRABYHSW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one
CAS: 195371-52-9
CID: 238484
Formula: C23H24N2O
MW: 344.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight344.4
XLogP34.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass344.188863393
Monoisotopic Mass344.188863393
Topological Polar Surface Area42.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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