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RA375

CAT: 1410-M34894-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M34894-01Size:2 mg
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Description
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
CAS Number
2649154-57-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
588.99
Molecular Formula
C30H25ClN4O7
Notes
Research use only, not for human use.
Receptor
Proteasome

Chemical Information

CID 146681207
CAS Number2649154-57-2
PubChem CID146681207
IUPAC NameN-[(2S)-1-[(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-4-oxopiperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]-2-chloroacetamide
Molecular FormulaC30H25ClN4O7
Molecular Weight589.0
XLogP4.7
Topological Polar Surface Area158
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count42
Formal Charge0
Complexity1020
SMILES
C\1N(C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C1=C/C3=CC=C(C=C3)[N+](=O)[O-])C(=O)[C@@H](NC(=O)CCl)CC4=CC=CC=C4
InChI
InChI=1S/C30H25ClN4O7/c31-17-28(36)32-27(16-20-4-2-1-3-5-20)30(38)33-18-23(14-21-6-10-25(11-7-21)34(39)40)29(37)24(19-33)15-22-8-12-26(13-9-22)35(41)42/h1-15,27H,16-19H2,(H,32,36)/b23-14+,24-15+/t27-/m0/s1
InChIKey
REFAVUFYPFWJGH-SWAPHQFDSA-N
Chemical Structure
2D Structure
2D structure of CID 146681207
CAS: 2649154-57-2
CID: 146681207
Formula: C30H25ClN4O7
MW: 589.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight589.0
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass588.1411768
Monoisotopic Mass588.1411768
Topological Polar Surface Area158 Ų
Heavy Atom Count42
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T36902-01RA375

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