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IL-4-inhibitor-1

CAT: 1410-M34855-01Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M34855-01Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM) . It is selective for IL-4 over IL-13 (EC50= 18.2 μM) . IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
CAS Number
1332184-63-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
321.31
Molecular Formula
C18H12FN3O2
Notes
Research use only, not for human use.
Receptor
IL Receptor

Chemical Information

IL-4-inhibitor-1
CAS Number1332184-63-0
PubChem CID136164931
IUPAC Name2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)pyridine-3-carbonitrile
Molecular FormulaC18H12FN3O2
Molecular Weight321.3
XLogP3.5
Topological Polar Surface Area103
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity474
SMILES
C1=CC(=CC=C1C2=NC(=C(C(=C2)C3=CC(=C(C=C3)O)O)C#N)N)F
InChI
InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)
InChIKey
DWZPPBGRCDPFSS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of IL-4-inhibitor-1
CAS: 1332184-63-0
CID: 136164931
Formula: C18H12FN3O2
MW: 321.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.3
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass321.09135480
Monoisotopic Mass321.09135480
Topological Polar Surface Area103 Ų
Heavy Atom Count24
Formal Charge0
Complexity474
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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