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G36

CAT: 1410-M33854-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M33854-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively) . G36 has no detectable binding activity to either ERα or ERβ. G36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF. G-36 can be used in combination with GPER-selective agonists, like G-1, to distinguish the roles of GPER from those of ERα and ERβ in complex biological systems.
CAS Number
1392487-51-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
412.32
Molecular Formula
C22H22BrNO2
Notes
Research use only, not for human use.
Receptor
Estrogen Receptor/ERR

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