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G36

CAT: 0804-HY-103450-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103450-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G-36 is a cell-permeable nonsteroidal antagonist of the G protein-coupled estrogen receptor (GPER/GPR30), which selectively inhibits estrogen-mediated PI3K activation through GPER, rather than Erα. G-36 also inhibits estrogen-mediated calcium mobilization (IC50=112 nM) . G-36 is promising for research in the field of cancer[1][2].
CAS Number
1392487-51-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/g36.html
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC(C1=CC2=C(N[C@@H](C3=C(Br)C=C(OCO4)C4=C3)[C@]5([H])[C@@]2([H])C=CC5)C=C1)C
Molecular Formula
C22H22BrNO2
Molecular Weight
412.32
Precautions
H302, H315, H319
References & Citations
[1]Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol. 2011 Nov;127 (3-5) :358-66.|[2]Yu X, et al. The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries. PLoS One. 2018 Jan 23;13 (1) :e0191418.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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