PAF (C16)

CAT: 1410-M33743-02Size: 2 mgDry Ice: NoHazardous: No

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CAT#:1410-M33743-02Size:2 mg

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Description

PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16) ) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR) . PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.

CAS Number

74389-68-7

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

523.68

Molecular Formula

C26H54NO7P

Notes

Research use only, not for human use.

Receptor

MAPK | MEK | Endogenous Metabolite | ERK

Chemical Information

Platelet-activating factor

2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine is a 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. It has a role as a beta-adrenergic antagonist, a vasodilator agent, an antihypertensive agent, a bronchoconstrictor agent and a hematologic agent.

CAS Number	74389-68-7
PubChem CID	108156
IUPAC Name	[(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Molecular Formula	C26H54NO7P
Molecular Weight	523.7
XLogP	6.5
Topological Polar Surface Area	94.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	26
Heavy Atom Count	35
Formal Charge	0
Complexity	546

SMILES

CCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C

InChI

InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

InChIKey

HVAUUPRFYPCOCA-AREMUKBSSA-N

Chemical Structure

2D Structure

CAS: 74389-68-7

CID: 108156

Formula: C26H54NO7P

MW: 523.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	523.7
XLogP3	6.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	26
Exact Mass	523.36379006
Monoisotopic Mass	523.36379006
Topological Polar Surface Area	94.1 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	546
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
MBS808197-01	C16
GTR19241429-01	C16 Ceramide (d16:1, C16:0)
B7227-10	PAF (C16)
HY-108635-01	C16-PAF
HY-W590669-01	C16-Dihydroceramide
HY-168764-01	C16 Galactosylceramide
TP3842-01	C16-pHD108
268065-01	C16-Ceramide
MBS565687-01	C16 Ceramide
GTR19156712-01	PKR-IN-C16

PAF (C16)

Chemical Information

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