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Lometrexol

CAT: 1410-M33418-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M33418-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
CAS Number
106400-81-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
443.45
Molecular Formula
C21H25N5O6
Notes
Research use only, not for human use.
Receptor
DHFR

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