AMG-1694

• Description:

  AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  533.63

• Molecular Formula:

  C23H30F3N3O4S2

• Notes:

  Research use only, not for human use.

• Receptor:

  Glucokinase

• CAS Number:

  1361217-07-3